Beyond weight loss: Exploring the anti-addiction effects of weight-loss injections

Jonathan J. Redeker, MD

February 7, 2025

The success of weight-loss injections

The success of weight loss injections lies primarily in their ability to support weight loss by suppressing appetite and promoting satiety. This blog allows you to explore the fascinating mechanisms by which the latest weight loss injections (GLP-1 receptor agonists) not only influence appetite and satiety, but also combat various forms of unhealthy behavior driven by cravings and addictions. It offers you new insights into the dynamics of pleasure, cravings and addiction.

Benefits of GLP-1 receptor agonists

Modulating brain systems that regulate cravings can significantly reduce the negative effects of cravings. In addition to the promising health benefits currently being studied, GLP-1 receptor agonists could also significantly reduce societal stigmatisation of people struggling with loss of control going far beyond appetite.

What are cravings?

Experiments that cause reductions in dopamine levels in humans reveal a dissociation between desire and pleasure. Although the subjects continue to experience pleasure from rewards, their motivation to obtain them is reduced. Desire appears to evolve into an autonomous entity within desire, driven by unconscious processes and beyond voluntary control.

Regulation of desire

Reducing the unhealthy aspects of cravings marks a significant advance in dealing with the enormous challenge of intense cravings and urges, particularly those associated with addictive behavior. A growing number of studies suggest that drugs in weight loss injections originally developed to treat diabetes and later approved for weight control due to their appetite-regulating effects via GLP-1 and GIP signaling pathways may provide unexpected and far-reaching benefits.

Change in setpoints in the brain

GLP-1 receptor agonists modulate individually programmed set points in the brain and offer a promising approach to combat various compulsive behaviors and addictions. My patients who receive weight-loss medications often report a significant decrease in unhealthy behaviors unrelated to eating.

Curb cravings

A potential mechanism of action of GLP-1 receptor agonists to reduce cravings may be that they reduce the importance that the unconscious motivational system places on the immediate acquisition of desires, thereby reducing cravings. Rather than directly inhibiting pleasure, these drugs could shift attention away from harmful objects and thus shift focus away from compulsive behavior patterns.

Addiction treatment

Reducing the intensity of the desire does not eliminate it, but rather fine-tunes the extent of the strongest desires. The exact mechanisms that lead to this effect are still being researched, but initial clinical studies are providing promising insights into the potential to reduce dependence on substances such as alcohol, nicotine and opioids.

However, further studies are needed to accurately determine the effectiveness of GLP-1 receptor agonists in the treatment of drug abuse. Some studies show positive results in reducing cravings for addictive substances.

The social impact of weight-loss injections

The widespread use of weight loss injections could lead to significant societal changes by potentially altering patterns of desire and behavior. As the effects appear to go beyond combating obesity, preventing heart disease and possibly drug abuse, the impact on collective interests and consumption habits could be significant.

Impact on the economy

Economic impacts are already being observed and expected, not only among grocers, but also among other companies that offer tempting and easily accessible consumer products and services. Such collective changes could have far-reaching consequences for the economy and social structures.

Less stigmatisation

It is believed that stigma around obesity and addiction will decrease. The availability and effectiveness of these drugs challenge the view of craving, addiction, and obesity as moral failings by viewing them as medical challenges that lie in the hard-to-control subconscious rather than in personal choices. Given that people find success with weight-loss injections relatively easily after long-term struggles, there is potential for a paradigm shift in how society perceives and treats these issues, towards greater empathy and understanding rather than judgment and stigmatisation.

Is treatment with GLP-1 receptor agonists suitable for me?

If you would like to find out more about what these medications can do, I would like to invite you to a consultation. Together with my Well-Being Partner companies, I offer you a variety of coaching, consulting and training programs that are designed to help you achieve your personal goals in a healthy, efficient and sustainable way.

REDEKER AESTHETICS supports you in your journey, whether you are already a high-performing and independent person or need more assistance!

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