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The use of polynucleotides in aesthetic medicine: A milestone in skin rejuvenation

Jonathan J. Redeker, MD

August 11, 2024

What are polynucleotides used for?

In recent years, aesthetic medicine has made significant advances, particularly in skin rejuvenation techniques. One of the most promising developments in this area is the use of polynucleotides. These natural, highly pure DNA molecules help optimize our approach to maintaining health, improving skin quality and skin rejuvenation. This blog explores the innovative application of polynucleotides in aesthetic medicine, highlighting their benefits, the application protocols and the scientific consensus supporting their effectiveness.

What are polynucleotides?

Polynucleotides are long DNA fragments obtained primarily from the gonads of trout. They possess unique viscoelastic properties that allow them to act as temporary fillers while promoting skin rejuvenation and self-healing. In contrast to conventional hyaluronic acid fillers, polynucleotides ensure more natural and profound tissue regeneration, resulting in healthier and more vital skin. The underlying principle is their ability to stimulate dermal fibroblast activity, resulting in improved skin elasticity, hydration and quality.

Clinical effects and consensus

A comprehensive consensus report from an expert team of dermatologists and plastic surgeons underlines the effectiveness and safety of polynucleotide-based treatments. The report, which includes clinical trial data and extensive practical experience, describes detailed protocols for the use of polynucleotides in various aesthetic procedures. An interesting clinical study with 143 patients showed a significant improvement in skin elasticity and hydration, with both patients and doctors being very satisfied. The study reported no significant side effects, highlighting the safety profile of polynucleotides. In addition, the experts reached a consensus on the treatment protocols for different areas of the face and body, providing a solid basis for their use in aesthetic medicine.

Treatment areas and protocols

The expert report contains recommendations for the use of polynucleotides in various areas, such as the face, eye area, décolleté and neck, hands and even scalp. For each area there are specific protocols for dosage, amount of injection and number of treatment sessions required.

Face

Highly concentrated polynucleotide formulations (40 mg/2 ml) are recommended for facial rejuvenation. You should receive an intradermal injection every 14 to 21 days, with the first treatment cycle comprising a total of four sessions. With advanced skin aging, sessions can be more frequent and take place every 7 days.

Eye area

Due to the sensitivity of the skin around the eyes, low concentration formulations are preferred. The same protocol is recommended with intradermal injections every 14 to 21 days for four sessions.

Cleavage and neck

These areas, which are often exposed to the sun and age quickly, also benefit from polynucleotide treatments. The protocol is similar to that of the face and aims to improve skin texture and hydration.

Hands

Hands quickly show signs of aging, and polynucleotide treatments can significantly improve skin quality and hydration in this area. The recommended approach is similar to that for other areas of the body and focuses on revitalization.

Scalp

Polynucleotides can normalize follicular activity and promote hair growth, so they are also beneficial for scalp treatments.

Benefits of Polynucleotide Treatments

The multiple benefits of polynucleotides in aesthetic medicine arise from their ability to treat various aspects of skin aging and damage.

Skin rejuvenation

Polynucleotides promote the production of collagen and elastin, essential for youthful and elastic skin.

Hydration

They improve skin hydration, which is essential for a healthy and radiant appearance.

Improvement of scars

Polynucleotides can improve the appearance of scars by promoting tissue regeneration.

Reduction of stretch marks

By stimulating the activity of dermal fibroblasts, polynucleotides help reduce the visibility of stretch marks.

Hair growth

When used for the scalp, polynucleotides can promote hair growth and improve follicle health.

Natural skin rejuvenation

The introduction of polynucleotides into aesthetic medicine represents a significant advance in the search for natural and effective skin rejuvenation techniques. Polynucleotides are well on their way to becoming a cornerstone of regenerative aesthetics, providing you with a natural cutting-edge treatment option, to maintain youthful and healthy skin and hair. As research and clinical application continue to evolve, polynucleotides are likely to play an increasingly important role in aesthetic medicine.